Gene Expression and Its Discontents Gene Expression and Its Discontents

Gene Expression and Its Discontents

The Social Production of Chronic Disease

    • 94,99 €
    • 94,99 €

Beschreibung des Verlags

This book describes how epigenetic context, in a large sense, affects gene expression and the development of an organism, using the asymptotic limit theorems of information theory to construct statistical models useful in data analysis. The approach allows deep understanding of how embedding context affects development. We find that epigenetic information sources act as tunable catalysts, directing ontogeny into characteristic pathways, a perspective having important implications for epigenetic epidemiology. In sum, environmental stressors can induce a broad spectrum of developmental dysfunctions, and the book explores a number of pandemic chronic diseases, using U.S. data at different scales and levels of organization. In particular, we find the legacy of slavery has been grossly compounded by accelerating industrial decline and urban decay. Individual chapters are dedicated to obesity and its sequelae, coronary heart disease, cancer, mental disorders, autoimmune dysfunction, Alzheimer’s disease, and other conditions. Developmental disorders are driven by environmental factors channeled by historical trajectory and are unlikely to respond to medical interventions at the population level in the face of persistent individual and community stress. Drugs powerful enough to affect deleterious epigenetic programming will likely have side effects leading to shortened lifespan. Addressing chronic conditions and developmental disorders requires significant large-scale changes in public policy and resource allocation.

GENRE
Gewerbe und Technik
ERSCHIENEN
2016
23. November
SPRACHE
EN
Englisch
UMFANG
357
Seiten
VERLAG
Springer International Publishing
GRÖSSE
3,9
 MB

Mehr Bücher von Rodrick Wallace & Deborah Wallace

Essays on the Extended Evolutionary Synthesis Essays on the Extended Evolutionary Synthesis
2023
Essays on Strategy and Public Health Essays on Strategy and Public Health
2022
Deception and Delay in Organized Conflict Deception and Delay in Organized Conflict
2022
The Recurrence of COVID-19 in New York State and New York City The Recurrence of COVID-19 in New York State and New York City
2022
Consciousness, Cognition and Crosstalk: The Evolutionary Exaptation of Nonergodic Groupoid Symmetry-Breaking Consciousness, Cognition and Crosstalk: The Evolutionary Exaptation of Nonergodic Groupoid Symmetry-Breaking
2021
Politics, Hierarchy, and Public Health Politics, Hierarchy, and Public Health
2019