When 57-year-old Ethan Zachary is ravaged by mysterious ball lightning, he starts growing progressively younger. As the condition begins to take hold, he realizes the end result will eventually kill him, ruining his plans to run for Congress - as well as his marriage. He does find a few compensations: his new youth and vigor attract a Cuban refugee reporter and a young lady lawyer, and his libido has been magically restored. Then a reclusive billionaire snatches "EZ" to use him as a medical guinea pig. But EZ's internal clock is reverse-aging him inexorably, with the pace accelerating exponentially.
As he navigates through the maze of his personal problems and political intrigue, his biological timepiece keeps winding backwards, tick, tick, tick - until all he knows is that the hours are running out, any way you count them. There's just one more thing he can try!