A Strong Interaction Between Serum [Gamma]-Glutamyltransferase and Obesity on the Risk of Prevalent Type 2 Diabetes: Results from the Third National Health and Nutrition Examination Survey (Lipids, Lipoproteins, And Cardiovascular Risk Factors)

A Strong Interaction Between Serum [Gamma]-Glutamyltransferase and Obesity on the Risk of Prevalent Type 2 Diabetes: Results from the Third National Health and Nutrition Examination Survey (Lipids, Lipoproteins, And Cardiovascular Risk Factors)

A Strong Interaction Between Serum [Gamma]-Glutamyltransferase and Obesity on the Risk of Prevalent Type 2 Diabetes: Results from the Third National Health and Nutrition Examination Survey (Lipids, Lipoproteins, And Cardiovascular Risk Factors‪)‬

Clinical Chemistry 2007, June, 53, 6

Clinical Chemistry

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Although increased serum y-glutamyltransferase (GGT)4 has been regarded as a biomarker of hepatobiliary disease and alcohol consumption, cellular GGT is an ectoplasmic enzyme responsible for the extracellular catabolism of glutathione and is widely distributed in various cells with high secretory or absorptive activities (1). Recent population-based epidemiological studies have shown a strong association of serum GGT activities within the reference interval with many cardiovascular disease risk factors or components of metabolic syndrome (2-14). In addition, in prospective studies, baseline serum GGT activity predicted future diabetes, hypertension, stroke, and myocardial infarction (3-14). Among these diseases, serum GGT within the reference interval most strongly predicted incident type 2 diabetes (5, 8-13).

GENRE

Science & Nature

RELEASED

2007

1 June

LANGUAGE

EN

English

LENGTH

18

Pages

PUBLISHER

American Association for Clinical Chemistry, Inc.

SELLER

The Gale Group, Inc., a Delaware corporation and an affiliate of Cengage Learning, Inc.

SIZE

249

KB

Role of GGT in Diagnosis of Metabolic Syndrome: A Clinic-Based Cross-Sectional Survey (Gamma-Glutamyl Transferase) (Report)

Role of GGT in Diagnosis of Metabolic Syndrome: A Clinic-Based Cross-Sectional Survey (Gamma-Glutamyl Transferase) (Report)

Role of GGT in Diagnosis of Metabolic Syndrome: A Clinic-Based Cross-Sectional Survey (Gamma-Glutamyl Transferase) (Report)

The Metabolic Syndrome: Requiescat in Pace.

The Metabolic Syndrome: Requiescat in Pace.

The Metabolic Syndrome: Requiescat in Pace.

Serum [Gamma]-Glutamyltransferase and Risk of Disease (Editorial)

Serum [Gamma]-Glutamyltransferase and Risk of Disease (Editorial)

Serum [Gamma]-Glutamyltransferase and Risk of Disease (Editorial)

Type 2 Diabetes: An Overview (Beckman Conference) (Clinical Report)

Type 2 Diabetes: An Overview (Beckman Conference) (Clinical Report)

Type 2 Diabetes: An Overview (Beckman Conference) (Clinical Report)

Effects of Resistance Training on Metabolic Profile of Adults with Type 2 Diabetes.

Prevalence & Risk Factors of Pre-Hypertension & Hypertension in an Affluent North Indian Population (Report)

Prevalence & Risk Factors of Pre-Hypertension & Hypertension in an Affluent North Indian Population (Report)

Prevalence & Risk Factors of Pre-Hypertension & Hypertension in an Affluent North Indian Population (Report)

Lowering Cutoffs for Initial and Confirmation Testing for Cocaine and Marijuana: Large-Scale Study of Effects on the Rates of Drug-Positive Results (Drug Monitoring and Toxicology)

Lowering Cutoffs for Initial and Confirmation Testing for Cocaine and Marijuana: Large-Scale Study of Effects on the Rates of Drug-Positive Results (Drug Monitoring and Toxicology)

Lowering Cutoffs for Initial and Confirmation Testing for Cocaine and Marijuana: Large-Scale Study of Effects on the Rates of Drug-Positive Results (Drug Monitoring and Toxicology)

Myocardial Infarction Redefined: Role of Cardiac Troponin Testing (Editorial)

Myocardial Infarction Redefined: Role of Cardiac Troponin Testing (Editorial)

Myocardial Infarction Redefined: Role of Cardiac Troponin Testing (Editorial)

Distribution of Fasting Plasma Insulin, Free Fatty Acids, And Glucose Concentrations and of Homeostasis Model Assessment of Insulin Resistance in a Representative Sample of Quebec Children and Adolescents (Pediatric Clinical Chemistry)

Distribution of Fasting Plasma Insulin, Free Fatty Acids, And Glucose Concentrations and of Homeostasis Model Assessment of Insulin Resistance in a Representative Sample of Quebec Children and Adolescents (Pediatric Clinical Chemistry)

Distribution of Fasting Plasma Insulin, Free Fatty Acids, And Glucose Concentrations and of Homeostasis Model Assessment of Insulin Resistance in a Representative Sample of Quebec Children and Adolescents (Pediatric Clinical Chemistry)

C677T and AI298C Polymorphisms of the Methylenetetrahydrofolate Reductase Gene: Incidence and Effect of Combined Genotypes on Plasma Fasting and Post-Methionine Load Homocysteine in Vascular Disease (Molecular Diagnostics and Genetics)

C677T and AI298C Polymorphisms of the Methylenetetrahydrofolate Reductase Gene: Incidence and Effect of Combined Genotypes on Plasma Fasting and Post-Methionine Load Homocysteine in Vascular Disease (Molecular Diagnostics and Genetics)

C677T and AI298C Polymorphisms of the Methylenetetrahydrofolate Reductase Gene: Incidence and Effect of Combined Genotypes on Plasma Fasting and Post-Methionine Load Homocysteine in Vascular Disease (Molecular Diagnostics and Genetics)

Acetylcholinesterase Activity and Biogenic Amines in Phenylketonuria (Technical Briefs)

Acetylcholinesterase Activity and Biogenic Amines in Phenylketonuria (Technical Briefs)

Acetylcholinesterase Activity and Biogenic Amines in Phenylketonuria (Technical Briefs)

Homocysteine, 5, 10-Methylenetetrahydrofolate Reductase 677CT Polymorphism, Nutrient Intake, And Incident Cardiovascular Disease in 24 968 Initially Healthy Women (Molecular Diagnostics and Genetics) (Clinical Report)

Homocysteine, 5, 10-Methylenetetrahydrofolate Reductase 677CT Polymorphism, Nutrient Intake, And Incident Cardiovascular Disease in 24 968 Initially Healthy Women (Molecular Diagnostics and Genetics) (Clinical Report)

Homocysteine, 5, 10-Methylenetetrahydrofolate Reductase 677CT Polymorphism, Nutrient Intake, And Incident Cardiovascular Disease in 24 968 Initially Healthy Women (Molecular Diagnostics and Genetics) (Clinical Report)