Aminoacyl-tRNA Synthetases in Biology and Medicine

1 Synthetic and Editing Mechanisms of Aminoacyl-tRNA Synthetases

John J. Perona, Ita Gruic-Sovulj

2 Emergence and Evolution

Tammy J. Bullwinkle, Michael Ibba

3 Architecture and Metamorphosis

Min Guo, Xiang-Lei Yang

4 Protein–Protein Interactions and Multi-component Complexes of Aminoacyl-tRNA Synthetases

Jong Hyun Kim, Jung Min Han, Sunghoon Kim

5 Extracellular Activities of Aminoacyl-tRNA Synthetases: New Mediators for Cell–Cell Communication

Sung Hwa Son, Min Chul Park, and Sunghoon Kim

6. Non-catalytic Regulation of Gene Expression by Aminoacyl-tRNA Synthetases

Peng Yao, Kiran Poruri, Susan A. Martinis, Paul L. Fox

7 Amino-Acyl tRNA Synthetases Generate Dinucleotide Polyphosphates as Second Messengers: Functional Implications

Sagi Tshori, Ehud Razin, Hovav Nechushtan

8 Association of Aminoacyl-tRNA Synthetases with Cancer

Doyeun Kim, Nam Hoon Kwon, Sunghoon Kim

9 Pathogenic Implications of Human Mitochondrial Aminoacyl-tRNA Synthetases

Hagen Schwenzer, Joffrey Zoll, Catherine Florentz, Marie Sissler

10 Role of Aminoacyl-tRNA Synthetases in Infectious Diseases and Targets for Therapeutic Development

Varun Dewan, John Reader, Karin-Musier Forsyth

11 Flexizymes, Their Evolutionary History and Diverse Utilities

Toby Passioura, Hiroaki Suga