Effects of Administration of Alpha-Melanocyte Stimulating Hormone ([Alpha]-Msh) on Some Hematological Values of Alloxan-Induced Diabetic Rats (Report‪)‬

American Journal of Pharmacology and Toxicology 2006, Jan, 1, 1

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Publisher Description

INTRODUCTION Diabetes Mellitus (DM) represents a heterogeneous group of disorders that have hyperglycemia as a common feature [1,2]. Al though Diabetes has long been considered a disease of minor significance, it is considered now as one of the main threats to human health in 21st century. Great changes in the human environment, behavior and lifestyle resulted in the raising rates of Diabetes [3]. (DM) is consequence of defects in secretion, insulin action or both, which is translated into abnormalities of carbohydrate, fat and protein metabolism resulting in hyperglycemia [4,5]. Symptoms of chronic hyperglycemia include polyuria, polydipsia and polyphagia as well as weight loss. Although varying among patients, long term complications of Diabetes can also include changes in arteries (arteriosclerosis), basement membranes of small vessels (microangiopathy), (kidneys (nephropathy), retina (retinopathy) and nerves (neuropathy) [6-8]. DM leads to many complications, such as increasing the risk of developing arterial disease by two to six folds [9]. It has been suggested that the heart rate is higher, red and white blood cells counts lower in type diabetes than in non-diabetic [10,11]. There is some evidence that diabetics present a deficiency in mounting an inflammatory response, probably associated with severe reduction in insulin secretion rather than increased blood glucose levels [1,2,13]. This is still a controversial point as other investigators have suggested a direct correlation between hyperglycemia and the incidence of infection in diabetic patients [14].

GENRE
Health & Well-Being
RELEASED
2006
1 January
LANGUAGE
EN
English
LENGTH
18
Pages
PUBLISHER
Science Publications
SIZE
254.7
KB

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