Diabetes Mellitus Type 3c, (Pancreatogenic Diabetes) A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions

This book describes Pancreatogenic Diabetes, Diagnosis and Treatment and Related Diseases
Just a week ago I was emailed an article on Pancreatogenic Diabetes
Intrigued I decided to look further into research papers and found that it is not as rare as it appeared.
Pancreatogenic diabetes is a form of secondary diabetes that occurs when pancreatic inflammation, neoplasia, or resection leads to beta-cell dysfunction, affecting the secretion of insulin causing Types 3c Diabetes.
Type 3c diabetes is almost twice as frequent as type 1 diabetes but is misdiagnosed as type 2 diabetes in over 87% of patients.
Type 3c diabetes patients tended about 1.5 times more likely to have poor glycemic control than those with type 2 diabetes and tended almost 10 times more likely to use insulin.
Those with type 3c diabetes need insulin therapy more urgently than those with type 2, so the result of this misdiagnosis are delays in giving proper treatment leading to nerve, eye, and kidney damage.
Causes:
1.Chronic pancreatitis is the most frequent disease of the exocrine pancreas linked with the development of diabetes
2.Cystic fibrosis-related diabetes (CFRD)
3.Lacking genes in the E2F group
4.Finally, other less frequent forms of pancreatogenic diabetes are present, such as that due to pancreatic cancer, and post-pancreatectomy diabetes
Symptoms:
These symptoms are typical of diabetes:
1. Frequent thirst even after drinking lots of water
2. Passing more frequent urine during day and night
3. Weight loss
Most patients with T3cDM have a known history of:
1. Pancreatitis with abdominal pain,
2. Steatorrhea or
3. Mal-digestion
4. Nutritional deficiencies and
5. Glucose intolerance.
Patients may also manifest with symptoms of:
1. Mal-digestion and
2. Abdominal pain
Diagnosis:
The diagnosis of T3cDM requires
1.The evidence of pancreatic exocrine insufficiency (based on monoclonal fecal elastase 1 test)
2.Evidence of pathological pancreatic imaging (by endoscopic ultrasound, MRI)
3.The absence of type 1 diabetes mellitus (T1DM)-linked auto-antibodies
Confirmation of T3cDM can then be made by report of an absent pancreatic polypeptide response to mixed-nutrient ingestion
Treatment:
The treatment of hyperglycemia to reach and maintain the HbA1c