Organizations are required to develop quick and accurate responses to internal and external changes that gain momentum. In this context, knowledge management activities become more important to all organizations. On the other hand, Geographic Information Systems (GIS) become common more and more. GIS which address a broad spectrum of users such as public agencies, local communities, civil society organizations, the private sector, academic environment, and personal users have been aiming to solve problems which occurred in location-based areas. GIS are important to get, combine, analyze and transfer the spatial data. Common use of PCs for personal needs, digital geography and improvements of software technologies, also the need to make socially acceptable business decisions facilitated development and widespread use of GIS applications. The main purpose of this paper is to discuss using areas and contribution potentials of GIS in enterprise-wide knowledge management processes.