INTRODUCTION Plasmodium falciparum and P. vivax are responsible for most of the global burden of malaria. More than two billion people are at the risk of contracting malaria (1), especially in the tropical and subtropical countries. Recent epidemiologic models, geographical and demographic data suggest that in India about two million confirmed cases and 1000 deaths are reported annually, although 15 million cases and 20,000 deaths are estimated by WHO-South East Asia Regional Office (SEARO), India. In the Southeastern Asian Region of WHO, of ~1.4 billion people living in 11 countries (land area, 8,466,600 [km.sup.2]; i.e. 6% of global area), 1.2 billion are exposed to the risk of malaria, most of whom live in India. However, Southeast Asia contributed to only 2.5 million cases to the global burden of malaria. Of this, India alone contributed 76% of total cases (2).