Lack of Effect of Stimulant Combination with Second-Generation Antipsychotics on Weight Gain, Metabolic Changes, Prolactin Levels, And Sedation in Youth with Clinically Relevant Aggression Or Oppositionality (Original Article‪)‬

Introduction CLINICALLY RELEVANT AGGRESSION AND oppositionality are common treatment targets in child and adolescent psychiatry (Pappadopulos et al. 2003; Schur et al. 2003; Olfson et al. 2006; Pappadopulos et al. 2006; Jensen et al. 2007). Disruptive behavior disorders that are frequently associated with relevant aggression and oppositionality occur in approximately 7-11% of the pediatric population (Loeber et al. 2000; Nock et al. 2007), with an estimated 75% referral rate to psychiatric care among children with these diagnoses (Arcelus and Vostanis 2003). Children suffering from these disorders and symptoms have problems functioning in families, in school, and with their peers. They are also at risk for long-term interpersonal and academic difficulty, legal problems, substance abuse or dependence, and frequent use of social and mental health services (Loeber et al. 2000; Ezpeleta et al. 2001; Nock et al. 2007).