Pathological Specimens and Genomic Medicine

Pathological Specimens and Genomic Medicine — Emerging Issues surveys various fields and medical disciplines related to the implementation of the new field of genomic medicine. The book includes sections on specimen processing, the effects of tissue fixation and storage impact on downstream molecular assays, image analysis and its role in the pathology workflow, molecular evaluation of samples, and how to present data to clinicians. The book contains examples of cases where these innovative technologies are applied in the real world, and also presents a look in to the future of the field of genomic medicine.
Contents:Introduction:Overview of Molecular Pathology and Genomic Medicine (Michael R Emmert-Buck)Molecular Pathology — Past, Present, and Future (Eli S Williams and Christopher A Moskaluk)Tissue Biorepositories, Sample Heterogeneity, and Microdissection:The Use of Biorepositories in Genomic Medicine (Rodrigo Chuaqui)Specimen Heterogeneity and Tissue Microdissection (Kristen D Noyes, Mary Kamos, Kevin B Delfino and Michael A Tangrea)Digital Imaging, Machine Learning, and Artificial Intelligence:Application and Practice of Digital Pathology (Joshua D Webster and Jeff Eastham-Anderson)The Future Role of Digital Imaging in the Pathology Workflow (Fumi Kawakami, Naohiro Uraoka and Yukako Yagi)Machine Learning for the Integration of Pathology Images with Molecular Data (Martin C Stumpe, Arran Schlosberg, Laura Deming, Lily Peng, Graziella Solinas and Jason Hipp)Artificial Intelligence in Pathology and Genomic Medicine (Philip A Pappalardo and Christopher B Townsend)Molecular Analysis — Issues, Challenges, and Successes:Applying High-Throughput Molecular Techniques to FFPE Clinical Tissues — DNA and mRNA (Chih-Jian Lih, Hala Makhlouf, P Mickey Williams, Scott M Lawrence, and Rodrigo Chuaqui)Proteomic Analysis of Archival Samples (Adele R Blackler)microRNAs in Tissue-Based Diagnosis and Prognosis: Possibilities and Limitations (Marc K Halushka)Informatics, Implementation, and Genomic Cohorts:Example of a Scalable and Adaptable Approach for NGS Analyses Leveraging High-Performance Computing (Cody Ashby, Michael A Bauer, Erich A Peterson, and Donald J Johann, Jr.)Kidney Diseases in the Age of Molecular Diagnostics: An Integrated Histopathologic and Molecular Approach (Marco Delsante, Jeffrey B. Kopp, and Avi Z Rosenberg)DICER1 Syndrome Testing: The Role of Molecular Pathology in Improving Diagnosis and Elucidating Pathogenesis (D Ashley Hill, Amanda Field, Mark A Brenneman, and Kris Ann Schultz)Precision Medicine: Challenges in Changing the Paradigm for Medical Care in the 21st Century (Timothy J O'Leary)
Readership: Graduate students, cancer researchers, geneticists, molecular pathologists, physician scientists and professional scientists interested in precision medicine.Molecular Pathology;Genomics;Biospecimens;Proteomics;Informatics;Digital Pathology0Key Features:The assembled expert authors present their unique perspective on the exciting field of genomic medicine