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Malaria Vaccine: A Current Perspective (Report)
Journal of Vector Borne Diseases 2008, March, 45, 1
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- 22,00 kr
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- 22,00 kr
Publisher Description
Introduction Our relationship with parasites has been a long one on the evolutionary scale. The methods adopted by parasites to thrive and colonize living organisms are truly fascinating. Along with basic features such as fecundity and resistant cyst structures, the parasites exhibit a fine-tuning of modifications in response to the attack by the host immune system. While the host fights the parasites through its armory of immune as well as certain behavioural responses, the parasites appear to use the host immune responses towards quorum sensing, limiting their own number, but surviving. The human malarial parasite, Plasmodium falciparum, which appears to have an ancient origin and has evolved in parallel with humans (1), is known to possess a complex arsenal of defences against man, and therefore the efforts to generate an effective malaria vaccine have been fraught with obstacles.