Chemoselective Reactions: Toward the Synthesis of Biologically Active Natural Products with Anticancer Activities (Report‪)‬

Abstract: Leucascandrolide A and migrastatin were synthesized efficiently by using chemoselective reactions such as olefin metatheses. The use of an iron-catalyzed cross-coupling reaction overcame difficulties encountered with palladium-catalyzed processes in our synthetic approach toward spirangien A. Keywords: natural products; total synthesis; crotyltitanation; allyltitanation; cross-metathesis; ring-closing metathesis; chemoselective reactions; cross-coupling; iron.