Effects of Water Extract of Usnea Longissima on Antioxidant Enzyme Activity and Mucosal Damage Caused by Indomethacin in Rats. Effects of Water Extract of Usnea Longissima on Antioxidant Enzyme Activity and Mucosal Damage Caused by Indomethacin in Rats.

Effects of Water Extract of Usnea Longissima on Antioxidant Enzyme Activity and Mucosal Damage Caused by Indomethacin in Rats‪.‬

Phytomedicine: International Journal of Phytotherapy & Phytopharmacology 2005, Sept, 12, 9

    • 2,99 €
    • 2,99 €

Description de l’éditeur

Abstract In this study, the antiulcerogenic effect of a water extract obtained from the lichen species Usnea longissima was investigated using indomethacin-induced ulcer models in rats. Experimental groups consisted of six rats. Antiulcerogenic activities of 50, 100 and 200 mg/kg body wt. doses of the water extract were determined by comparing the negative (treated only with indomethacin) and positive (ranitidine) control groups. Although all doses of the water extract of U. longissima showed significant antiulcerogenic activity as compared to negative control groups, the highest activity was observed with 100 mg/kg body wt. doses (79.8%). The water extract of U. longissima showed moderate antioxidant activity when compared with trolox and ascorbic acids used as positive antioxidants. In addition, the activities of antioxidant enzymes [superoxide dismutase (SOD), catalase (CAT) and glutathione S-transferase (GST)] were determined in the stomach tissues of rats and compared with those of the negative and positive control groups to expose the effects of antioxidant enzymes on antiulcerogenic activity. SOD and GST enzymes activities in indomethacin-administrated tissues were reduced significantly by indomethacin in comparison to control groups. These enzymes were activated, however, by the water extracts of U. longissima. In contrast to SOD and GST activities, CAT activity was increased by indomethacin and reduced by all doses of U. longissima and ranitidine. The present results indicate that the water extract of U. longissima has a protective effect in indomethacin-induced ulcers, which can be attributed to its antioxidant potential.

GENRE
Science et nature
SORTIE
2005
1 septembre
LANGUE
EN
Anglais
LONGUEUR
20
Pages
ÉDITIONS
Urban & Fischer Verlag
TAILLE
225,6
Ko

Plus de livres similaires

Anti-Ulcer and Anti-Oxidant Activity of Pepticare, A Herbomineral Formulation. Anti-Ulcer and Anti-Oxidant Activity of Pepticare, A Herbomineral Formulation.
2005
Adaptogenic Activity of Glyco-Peptido-Lipid Fraction from the Alcoholic Extract of Trichopus Zeylanicus Gaerten (Part II). Adaptogenic Activity of Glyco-Peptido-Lipid Fraction from the Alcoholic Extract of Trichopus Zeylanicus Gaerten (Part II).
2005
Tinospora Cordifolia Induces Enzymes of Carcinogen/Drug Metabolism and Antioxidant System, And Inhibits Lipid Peroxidation in Mice. Tinospora Cordifolia Induces Enzymes of Carcinogen/Drug Metabolism and Antioxidant System, And Inhibits Lipid Peroxidation in Mice.
2006
Isolation and Characterisation of Protoberberines with Antioxidant, Antiproliferative and Protease Inhibitory Activity from Berberis Aristata Isolation and Characterisation of Protoberberines with Antioxidant, Antiproliferative and Protease Inhibitory Activity from Berberis Aristata
2015
Nutraceuticals and Natural Product Derivatives Nutraceuticals and Natural Product Derivatives
2018
Antioxidant-Based Therapies for Disease Prevention and Management Antioxidant-Based Therapies for Disease Prevention and Management
2021

Plus de livres par Phytomedicine: International Journal of Phytotherapy & Phytopharmacology

Quality of Life in Breast Cancer Patients During Chemotherapy and Concurrent Therapy with a Mistletoe Extract (Clinical Report) Quality of Life in Breast Cancer Patients During Chemotherapy and Concurrent Therapy with a Mistletoe Extract (Clinical Report)
2011
Antimicrobial Activity of Various Extracts and Carvacrol from Lippia Multiflora Leaf Extract. (Short Communication). Antimicrobial Activity of Various Extracts and Carvacrol from Lippia Multiflora Leaf Extract. (Short Communication).
2003
A Review on Potentiality of Medicinal Plants As the Source of New Contraceptive Principles. (Review). A Review on Potentiality of Medicinal Plants As the Source of New Contraceptive Principles. (Review).
2003
Tolerance, Safety and Efficacy of Hedera Helix Extract in Inflammatory Bronchial Diseases Under Clinical Practice Conditions: A Prospective, Open, Multicentre Postmarketing Study in 9657 Patients (Report) Tolerance, Safety and Efficacy of Hedera Helix Extract in Inflammatory Bronchial Diseases Under Clinical Practice Conditions: A Prospective, Open, Multicentre Postmarketing Study in 9657 Patients (Report)
2009
Complexities of the Herbal Nomenclature System in Traditional Chinese Medicine (TCM): Lessons Learned from the Misuse of Aristolochia-Related Species and the Importance of the Pharmaceutical Name During Botanical Drug Product Development. Complexities of the Herbal Nomenclature System in Traditional Chinese Medicine (TCM): Lessons Learned from the Misuse of Aristolochia-Related Species and the Importance of the Pharmaceutical Name During Botanical Drug Product Development.
2007
The Need for Establishing Identities of 'Bacoside A and B', the Putative Major Bioactive Saponins of Indian Medicinal Plant Bacopa Monnieri (Short Communication) The Need for Establishing Identities of 'Bacoside A and B', the Putative Major Bioactive Saponins of Indian Medicinal Plant Bacopa Monnieri (Short Communication)
2004