• 184,99 €

Description de l’éditeur

This
essential volume comprehensively discusses redox-active therapeutics, focusing
particularly on their molecular design, mechanistic, pharmacological and
medicinal aspects.  The first section of the book describes the basic
aspects of the chemistry and biology of redox-active drugs and includes a brief
overview of the redox-based pathways involved in cancer (such as the role of
mitochondria, hydrogen peroxide and endogenous antioxidative defenses) and the
medical aspects of redox-active drugs, assuming little in the way of prior
knowledge. The second section encompasses several major classes of redox-active
experimental therapeutics, which include porphyrins, salens, nitrones, and
other metal-containing (e.g., Mn, Fe, Cu, Zn, Sb) drugs as either single
compounds or formulations with nanomaterials and quantum dots. Subsequent
sections and chapters describe more specialized aspects of redox-active
therapeutics in clinical disorders, such as cancer, cardiovascular diseases,
diabetes, central nervous system injuries, neurodegenerative diseases, pain, radiation
injury and radioprotection (such as of brain, lungs, head and neck and erectile
function) and neglected diseases (e.g., leishmaniasis). Numerous illustrations, tables
and figures enhance and complement the text; extensive references to relevant
literature are also included.

Redox-Active Therapeutics is an invaluable addition
to Springer’s Oxidative Stress in Applied Basic Research and Clinical
Practice
series.  It is essential reading for researchers, clinicians
and graduate students interested in understanding and exploring the
Redoxome—the organism redox network—as an emerging frontier in drug design,
redox biology and medicine.

GENRE
Science et nature
SORTIE
2016
13 octobre
LANGUE
EN
Anglais
LONGUEUR
724
Pages
ÉDITIONS
Springer International Publishing
TAILLE
11,3
Mo