When creatures of the night proved to be real, the best of America's military came together to form an elite band of rapid response teams. Their mission: to keep the civilian populace safe from monsters that would do harm and hide all evidence of their existence. Now they face a threat so overwhelming that they must pull teams from across the globe and work with the very monsters they've hunted in the past to assist them in saving humanity.
As the largest threat ever to rise against mankind prepares its own twisted apocalypse, the only thing standing in its way is the Monster Squads. Man and monster will fight side by side in an epic battle to the death to try to defeat an evil so great, it could only have been created by God himself.