In 1963, CDC research scientist, Dr. Liam Frank, travels to Uganda to reunite with his girlfriend Penny and treat patients at a Peace Corps camp where she's teaching grade school. The minute he arrives, however, he's hijacked by Mwana, a master strategist from the war-torn Belgian Congo, who has far different plans for the talented disease control physician. Despite Liam's desire to prove himself to Penny, he's coerced into the lab to try to isolate and control a horrific new disease called Scream -- which drags its victims through a bloody, screaming hell and leaves no survivors. In a tightly played game of pawns, knights and would-be kings, Liam is cast in the role of pawn. To survive and rescue Penny, he'll need to become a hero.