Biomarker Discovery and Validation (Editorials) Biomarker Discovery and Validation (Editorials)

Biomarker Discovery and Validation (Editorials‪)‬

Clinical Chemistry, 2006, Sept, 52, 9

    • £2.99
    • £2.99

Publisher Description

Currently available biomarkers, such as those used to diagnose myocardial infarction (e.g., cardiac troponins), were identified in the course of targeted physiologic studies. Similarly, basic investigation of diseases has largely been characterized by studies of isolated molecules in cellular systems. Advances in genomics technologies, however, are beginning to permit characterization of global alterations associated with disease conditions and, in the process, identification of novel biomarkers and pathways. Laterza et al. (1) used such a global survey, and in this issue of Clinical Chemistry they describe their discovery of potential new markers related specifically to brain injury. Now begins the long road toward validation of these markers in clinically relevant human cohorts. Although no serum biomarkers of brain injury for conditions such as stroke are in clinical use, they could ultimately prove to be of enormous clinical usefulness to complement physical and radiologic examinations, both of which can be ambiguous during acute presentations. Of the multiple genomics applications, perhaps none has garnered more recent attention for biomarker discovery than proteomics. Proteomics offers unique insight into disease because proteins and their bioenzymatic functions largely determine the phenotypic diversity that can arise from a set of common genes. Posttranslational modifications help regulate structure, function, localization, maturation, and turnover of proteins. Because the entire complement of expressed proteins in their various forms can rapidly change in response to environmental cues, the proteome represents the unique ensemble of proteins that reflects the state of the cell or group of cells at a given time, in a particular context under particular stimuli. Thus, the proteome is highly dynamic, in contrast to the stability of the genome.

GENRE
Science & Nature
RELEASED
2006
1 September
LANGUAGE
EN
English
LENGTH
9
Pages
PUBLISHER
American Association for Clinical Chemistry, Inc.
SIZE
155.4
KB

More Books Like This

Proteomics: A New Diagnostic Frontier (Minireview) Proteomics: A New Diagnostic Frontier (Minireview)
2006
Immunoassay Standardization: Is It Possible, Who Is Responsible, Who Is Capable?(Opinion) (Clinical Report) Immunoassay Standardization: Is It Possible, Who Is Responsible, Who Is Capable?(Opinion) (Clinical Report)
2001
Standards for Plasma and Serum Proteomics in Early Cancer Detection: A Needs Assessment Report from the National Institute of Standards and Technology-National Cancer Institute Standards, Methods, Assays, Reagents and Technologies Workshop, August 18-19, 2005 (Overview) Standards for Plasma and Serum Proteomics in Early Cancer Detection: A Needs Assessment Report from the National Institute of Standards and Technology-National Cancer Institute Standards, Methods, Assays, Reagents and Technologies Workshop, August 18-19, 2005 (Overview)
2006
Bioanalytical Aspects in Biological Therapeutics Bioanalytical Aspects in Biological Therapeutics
2022
Molecular Epidemiology of Chronic Diseases Molecular Epidemiology of Chronic Diseases
2011
Integration of Omics Approaches and Systems Biology for Clinical Applications Integration of Omics Approaches and Systems Biology for Clinical Applications
2018

More Books by Clinical Chemistry

Single-Nucleotide Polymorphism Allele Frequencies Determined by Quantitative Kinetic Assay of Pooled Dna (Technical Briefs) Single-Nucleotide Polymorphism Allele Frequencies Determined by Quantitative Kinetic Assay of Pooled Dna (Technical Briefs)
2002
Interlaboratory Comparison of Fetal Male DNA Detection from Common Maternal Plasma Samples by Real-Time Pcr (Molecular Diagnostics and Genetics) Interlaboratory Comparison of Fetal Male DNA Detection from Common Maternal Plasma Samples by Real-Time Pcr (Molecular Diagnostics and Genetics)
2004
High Concentrations of Excised Oxidative DNA Lesions in Human Cerebrospinal Fluid (Technical Briefs) High Concentrations of Excised Oxidative DNA Lesions in Human Cerebrospinal Fluid (Technical Briefs)
2003
Doping in Sport: Misuse, Analytical Tests, And Legal Aspects (Editorial) Doping in Sport: Misuse, Analytical Tests, And Legal Aspects (Editorial)
1997
Relationship Between Genetic Polymorphisms of Alcohol-Metabolizing Enzymes and Changes in Risk Factors for Coronary Heart Disease Associated with Alcohol Consumption (Lipids, Lipoproteins, And Cardiovascular Risk Factors) Relationship Between Genetic Polymorphisms of Alcohol-Metabolizing Enzymes and Changes in Risk Factors for Coronary Heart Disease Associated with Alcohol Consumption (Lipids, Lipoproteins, And Cardiovascular Risk Factors)
2002
Detection of Mycobacterium Tuberculosis by Real-Time PCR Using Pan-Mycobacterial Primers and a Pair of Fluorescence Resonance Energy Transfer Probes Specific for the M. Tuberculosis Complex (Technical Briefs) Detection of Mycobacterium Tuberculosis by Real-Time PCR Using Pan-Mycobacterial Primers and a Pair of Fluorescence Resonance Energy Transfer Probes Specific for the M. Tuberculosis Complex (Technical Briefs)
2003