DNA

PUBLISHERS WEEKLY 3 MAR 2003

Who better than James Watson to lead a guided tour of DNA? When he and his English colleague, Francis Crick, discovered the double helix structure of the DNA molecule in 1953, little could they imagine that a mere 50 years later scientists would be putting the finishing touches on a map of the human genome. In this magisterial work, Watson, who won the Nobel Prize with Crick for their discovery, guides readers through the startling and rapid advances in genetic technology and what these advances will mean for our lives.Watson covers all aspects of the genome, from the layout of four simple bases on the DNA molecule through their complex construction into genes, then to the mechanisms whereby proteins produced by genes create our uniquely human characteristics as well as the genetic mutations that can cause illnesses or inherited diseases like Duchenne muscular dystrophy and Huntington's disease.Watson may have mellowed a little over the years since he displayed his youthful brashness in The Double Helix, but he still isn't shy about taking on controversial subjects. He criticizes biotech corporations for patenting genes, making diagnostic medical procedures horribly expensive and damping further basic research. He notes that while China and other countries with large populations to feed have eagerly grasped the potential of genetically modified foodstuffs, America squandered $100 million on a recall of taco shells and the genetically modified corn used in them. He pleads passionately for the refinement and widespread use of prenatal genetic testing. Watson will probably provoke the most controversy with his criticism of scientists, corporations and government funding sources for their avoidance of important areas of research notably the genetics of skin coloration for political reasons. Every reader who wants to understand their own medical future will want to read this book. 100 color and b&w illus. 150,000 first printing; BOMC and History Book Club selection. FYI:A five-part PBS series on DNA featuring Watson will air later this year.