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Failure to adjust dosing of renally excreted drugs in patients with renal impairment may lead to adverse effects, including nephrotoxicity. The incidence of in-hospital acute kidney injury attributed to drug nephrotoxicity is estimated at 19%.1 Drug-induced nephrotoxicity and adverse effects can be reduced by adjusting the dosing of renally excreted drugs according to the patient's estimated glomerular filtration rate (eGFR), but this is often neglected by prescribers. In renally impaired patients, 29-74% of drug prescriptions requiring dose adjustment are not appropriately adjusted. (2-7) We conducted a retrospective cross-sectional study to determine the prevalence of incorrect dosing of renally eliminated drugs among general medical patients with renal impairment at Groote Schuur Hospital (GSH), Cape Town. We aimed to determine what proportion of drugs prescribed to patients with renal impairment (defined as an eGFR of [less than or equal to]50 ml per minute per 1.73 m2) in the general medical wards required dose adjustment; and to determine whether drug doses were appropriately adjusted in these patients, using Drug Prescribing in Renal Failure as our reference for dose adjustments. (8)

GENRE
Health & Well-Being
RELEASED
2010
May 1
LANGUAGE
EN
English
LENGTH
9
Pages
PUBLISHER
South African Medical Association
SIZE
207.6
KB

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