Biotherapeutic proteins, which include antibodies, are becoming the fastest growing category of drugs due to their efficacy for patient health. The complex nature of these large molecules brings major new challenges to the pharmaceutical scientist. The industry is undergoing a scientific revolution as it adapts to meet the challenges of characterizing biotherapeutics.
Glycosylation of biotherapeutic medicines plays a critical role in the efficacy of the drug. In-depth characterization of these glycans (complex sugars) bound to the drug entity is mandatory and challenging. To overcome this challenge, we have developed a series of four simple workflow solutions based on leading technology platforms.
Here we present workflows for the analysis of glycans in a simple graphical flow, with embedded media and details on enabling technologies for the modern biochemist.