Relevance of Parvovirus B19, Herpes Simplex Virus 2, and Cytomegalovirus Virologic Markers in Maternal Serum for Diagnosis of Unexplained Recurrent Abortions (Report‪)‬

Some evidence suggests that intrauterine infections play a major role in the pathogenesis of early pregnancy loss, but the implication and prevalence of microorganisms in the etiology of spontaneous abortion during the first trimester of pregnancy has not yet been well established. (1) Cytomegalovirus (CMV) and parvovirus B19 are linked to both late abortion and stillbirth. (2,3) Parvovirus B19 infections are associated with different clinical manifestations that vary from asymptomatic to severe symptoms. The main clinical manifestations are erythema infectiosum, transient aplastic crisis in individuals with hemoglobinopathies, chronic anemia in the immunocompromised patients, acute polyarthralgia syndrome in adults, hydrops fetalis, spontaneous abortion, and stillbirth. (4,5)