Intensive Lipid Reduction and Proinflammatory Markers in the MODEST Study/ MODEST Calismasinda Yogun Lipid Dusurucu Tedavi Ve Proinflematuvar Belirtecler (Original Article/Orijinal Makale) (Report‪)‬

Introduction Atherosclerotic diseases are the leading causes of death in the developed world (1). Numerous clinical trials of hydroxmethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) have demonstrated a significant reduction in cardiovascular events (2). Although the majority of effects could be ascribed to a beneficial effect on the lipid profile, the statins exert beneficial effect, called pleiotropic effect, beyond those predicted by their cholesterol-lowering actions. Pleiotropic effects of statins include improvement in endothelial function, reduction of oxidative stress and inhibition of inflammatory stress (3). Statin therapy is well known to reduce inflammatory markers such as hsCRP, IL-6, TNF-[alpha] (4-5). However, whether this relationship is maintained in the setting of targeting very low levels of LDL (70 mg dl) in patients with type 2 diabetes has not been clearly established.