Changes of Plasma Metabolites, Hormones, And Mrna Expression of Liver PEPCK-C in Spontaneously Ketotic Dairy Cows (Report‪)‬

INTRODUCTION Ketosis is a major metabolic disease of many dairy cows in early lactation, and occurs frequently in high yielding cows. It is extremely detrimental for milk performance and reproductive ability of dairy cows. The decrease of DMI and increase of demand in the transition period may result in negative energy balance (NEB) of dairy cows, which can stimulate gluconeogenesis and fat mobilization. The adaptive accommodation by the metabolic and endocrine system plays an important role in the relief of NEB in the transition period. Once NEB cannot be restored, ketone body production increases and ketosis is unavoidable (Veenhuren et al., 1991; Dale et al., 1997).