Development of Transition-Metal-Catalyzed Cycloaddition Reactions Leading to Polycarbocyclic Systems (Report‪)‬

INTRODUCTION Despite the enormous development of organic synthesis during the recent decades, the preparation of biomedical relevant natural products featuring relatively complex polycyclic skeletons is inefficient and requires a high number of steps. This represents an important drawback if one wants to obtain reasonable amounts of this type of products in a reasonable period of time. In order to progress in this direction and streamline the process of building complex polycyclic molecules, it is critical to invent new types of synthetic technologies that allow the assembly of these compounds from readily available starting materials, in few steps, using safe and inexpensive reagents, preferably catalysts, and producing a minimal amount of waste [1].