Use of Functionalized [Beta]-Lactams As Building Blocks in Heterocyclic Chemistry (Report‪)‬

INTRODUCTION The class of [beta]-lactam antibiotics is generally recognized as a cornerstone of human health care due to the unparalleled clinical efficacy and safety of this type of antibacterials [1]. For example, the world antibiotics market is dominated by Augmentin, a combination of amoxicillin 1 and potassium clavulanate 2, produced by GlaxoSmithKline. Nevertheless, the recent appearance of highly resistant bacteria profoundly challenges the way medicinal chemists contemplate innovation of the [beta]-lactam structure and corroborates the need for continuous efforts within this field of research.