Fibroblast Growth Factors: Biology and Clinical Application

The fibroblast growth factor (FGF) family of ligands and the corresponding family of FGF receptor tyrosine kinases comprise one of the most versatile and diverse growth factor signaling families in vertebrates, found virtually in every tissue and cell type where they regulate metabolic and physiologic function, maintain tissue homeostasis, and mediate injury response, tissue repair, and regeneration. As a result, FGFs play critical roles in a wide variety of normal biological and abnormalities in FGF signaling can lead to a variety of disease states from developmental malformations, to atherosclerosis, pulmonary hypertension and cancer among many others. A thorough understanding of this system is necessary for critical insights into both normal and disease biology and is essential to development of rationale therapeutic strategies aimed at treatment of FGF-dependent diseases states.

Recent years have seen advances in our understanding of FGFs role in endothelial and, more general, vascular biology, the subject of this book. In particular, FGFs have been implicated in the maintenance of vascular homeostasis and control of blood vessel permeability while aberrant FGF signaling has been shown to be central to the development of pulmonary hypertension, and endothelial-to-mesenchymal transition, a process implicated in the development of atherosclerosis. Finally, FGFs ability to stimulate blood vessel growth has been explored in therapeutic angiogenesis approaches.

With this in mind, the present monograph is structured to provide comprehensive information to a reader interested in FGFs in general and vascular biology in particular. To this end, we explore everything from the structure and signaling of FGFs and their receptors (Chapters 1, 2 and 3) to their role in the regulation of vascular homeostasis (Chapter 4) and cardiovascular diseases (Chapters 5 and 6). We then address new developments in FGF therapeutics (chapter 7) and explore FGF biology in the epithelium (Chapter 8) thereby providing a complete analysis of this growth factor family biology in two closely related but distinctly different environments — endothelium and epithelium. Finally, we examine FGF biology in eye disease and in cancer.

It is our hope that this comprehensive treatment of FGF vascular biology and its application will provide the reader with the accurate and timely summary of this rapidly moving field.
Contents:An Introduction to the Fibroblast Growth Factors (David M Ornitz and Nobuyuki Itoh)Regulation of FGF Signaling (Robert E Friesel)FRS2α: At the Center of FGF Signaling (Cong Wang, Wallace L McKeehan and Fen Wang)Fibroblast Growth Factor Signaling, Endothelial Homeostasis, and Endothelial Cell to Mesenchymal Transition (Pei-Yu Chen and Michael Simons)FGF in Cardiovascular Disease (Surovi Hazarika and Brian H Annex)FGF Signaling in Pulmonary Hypertension (Irinna Papangeli and Hyung J Chun)Therapeutic Potential of Allosteric Modulation of FGF Receptors (Frederik De Smet and Peter Carmeliet)Fibroblast Growth Factors in Epithelial Homeostasis and Repair (Michael Meyer, Luigi Maddaluno and Sabine Werner)Growth Factors in the Eye (Rong Ju, Chunsik Lee, Weisi Lu and Xuri Li)FGF Ligand Traps for the Therapy of FGF-Dependent Tumors (Marco Rusnati, Marco Presta and Roberto Ronca)
Readership: People working in the field of FGF/FGF signaling: investigators, students and clinicians; vascular biologists and trainees in vascular biology. The book is also suitable for graduate courses on FGF biology, RTFs or vascular biology.