Hepatoprotective Effect of Bacoside-a, A Major Constituent of Bacopa Monniera Linn (Report‪)‬

Abstract Bacoside-A (B-A) was evaluated for its hepatoprotective activity against D-GalN induced liver injury in rats. B-A is a major constituent isolated from the plant Bacopa monniera Linn. B-A (10 mg/kg of body weight) was administered orally once daily for 21 days and then D-GalN (300 mg/kg of body weight) was injected on 21st day after final administration of B-A. B-A reduces the elevated levels of serum alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), [gamma]-glutamyl transferase ([gamma]-GT), lactate dehydrogenase (LDH), 5' nucleotidase (5'ND). In addition B-A also significantly restored towards normalization of the decreased levels of Vit-C, and Vit-E induced by D-GalN both in liver and plasma. These results suggest that B-A has hepatoprotective effect against D-GalN induced hepatotxicity in rats. [c] 2007 Elsevier GmbH. All rights reserved.