Wound Healing in Spontaneous Perforation Or Myringotomy and Middle Ear Reconstruction‪.‬

Concerns have been raised about the potential for ototopical agents to adversely affect middle ear or tympanic wound healing. In general, wound healing takes place in three phases--inflammation, proliferation, and maturation (1): * The inflammatory phase begins at the moment of injury with an immediate vasoconstriction response. Approximately 10 minutes later, vasodilation begins, and it lasts for up to 3 days. Within minutes of the onset of vasodilation, a cellular response occurs that persists for up to 1 week. The cellular response overlaps with the onset of the proliferative phase.