Zenox

Zenox is a true story; or rather it is the most optimistic of possible true stories about the survival of the human race after an explosion in the year AD 2020 hurled a stockpile of bio germs high into the stratosphere where jet streams dispersed its lethal spores. As the spores drifted back to Earth, they wiped out all humans.
Except 175 scientists and engineers of mixed age, race, religion and genders orbiting Earth in Space Station, Skylab 10, and 25 female scientists aboard Lady Endeavor halfway on a multiyear expedition to explore the moons of Saturn.
The survivors sardonically called their abode in the sky Heaven. They sought new mates; engaged in risky space missions to make room for their growing families; and remotely programmed from Heaven the super computers (Zenox) on Earth with artificial intelligence and the instinct to survive.
As a result, super Zenox began to evolve and by the year AD 2100, they had evolved into conscious beings called Zenox. But it was war, and the threat of war between the various Zenox factions that spurred their rapid evolution onward climaxed in the year AD 2270, with war with humans for mastery of Earth.