Chronic Administration of Methylphenidate Induces Lipid Peroxidation in the Striatum of Young Rats/Uzun Sureli Metilfenidat Verilmesi Genc Sicanlarin Striatumunda Lipid Peroksidasyonunu Indukler (Research Article/Arastirma Makalesi) (Report‪)‬

Introduction Attention-deficit hyperactivity disorder (ADHD) is the most-commonly diagnosed neurobehavioral disorder of childhood, which is estimated to affect between 3% and 7% of school-age children, making it a major public health concern 111. The use of amphetamine-like stimulants, particularly methylphenidate (MPH1, is considered as the best pharmacotherapy available in the treatment of children with ADHD (2,3) and their efficacy and tolerability in children have been reported in numerous studies (4) Furthermore, the psychostimulants represent the first stage of medication intervention for ADHD (5) Treatment with MPH can Dergisi, Galenos Vayincilik tarafindan basilmistir. Herhakki saklidir. begin early in the preschool period and often continues into adulthood (6,7). Therefore, much research is conducted to gain a thorough understanding of the exact mechanisms underlying therapeutic and potential adverse long-term effects of MPH treatment on the brain.