Pharmacokinetics

This book is based on a course in Basic Pharmacokinetics and a graduate level Pharmacokinetics course.


Chapters include:


Introduction

Background Mathematics

One Compartment IV Bolus

Analysis of Urine Data

Intravenous Infusion

Routes of Drug Administration

Pharmacokinetics of Oral Administration

Calculation of Bioavailability Parameters

Bioavailability Studies

Physiological Factors Affecting Oral Absorption

Physical-Chemical Factors Affecting Oral Absorption

Formulation Factors

Multiple IV Bolus Dose Administration

Multiple Oral Dose Administration

Excretion

Metabolism

Drug Distribution

Multi-Compartment Pharmacokinetic Models

Noncompartmental Analysis

Non-Linear Pharmacokinetic Models

Pharmacodynamic and Physiologically Based Pharmacokinetic Models

Pharmaceutical Analysis

Clinical Applications of Pharmacokinetics

Non-Linear Regression Analysis of Pharmacokinetic Data

Integrating Differential Equations using Laplace Transforms

Numerical Integration

Optimization

Weighting Data

Selection of the "Best" Model

Identifiability

Optimal Sampling