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It's time for them to answer the ultimate question: is one life worth the cost of millions?
CIA and CDC team Jesse and Maggie Cabot are back – this time to obtain and deliver the vaccine to ARVID-17, the super flu sweeping the country and killing people in the millions.
The mission directive was supposed to be simple: get to Portland, retrieve the world's last vaccine, and deliver to the CDC in San Francisco. But when their train derails and they are left stranded in the Oregon forest, it's up to Jesse and Maggie to find their own way south; but will their fragile marriage even survive this?
An abandoned train in the wilderness might be their lifeline, and they should have expected the malady within.