Site Specific and Global Epigenomic Editing

Site Specific and Global Epigenomic Editing: Principles and Applications, Volume 33 highlights the expanding role that epigenetics plays in pathogenesis, the full range of sites for possible epigenetic modification, and the potential to target these sites to modulate disease progression. The book answers key questions, including which of the hundreds of epigenomic marks and features are relevant, and which are likely to serve a role in regulating gene expression, cell behavior and phenotypic outcomes. This volume is the first to provide a thorough, conceptual introduction to epigenetic regulation and a thorough accounting of sites for possible epigenetic edits and disease modulation. Included protocols and applied case studies examine early disease targets and likely pathways of therapeutic significance while also outlining common challenges in the field. The book addresses its topic in a comprehensive, but accessible manner, highlighting practical tools and burning questions remaining in the field to enable fresh research.

- Offers a full, conceptual and applied framework for implementing epigenomic editing in biological research and drug discovery

- Discusses fundamental theory, experimental design and applied approaches alongside common research challenges and bioethical concerns

- Examines epigenomic editing's potential role in the modulation of developmental, neuropsychiatric and immunological disorders, as well as in viral infections and cancer