Transistor

When Naomi Woodward's doctor recommended her for a clinical trial, it seemed like the answer to her prayers. She was finally able to get her gender confirmation surgery and the surgery was a resounding success. She finally looked and felt like the woman she always knew she was.
Her new face and new body finally helped her work up the nerve to ask out Anika, the beautiful nurse that lived across the hall. To her delight Anika said yes, but when they are attacked during their date, Naomi quickly discovers that the experimental procedure she went through had some unexpected side effects, and that when Anika told her things with her family were complicated, she really should have listened.
Now, armed with superpowers she barely understands, a snarky artificial intelligence in her head, and allies that include a Superhero, a Dragon, and the literal Devil, she has to keep Anika safe from the archangel who's out to kill her while they work desperately to prevent a second civil war in heaven.