Compendium of In Vivo Monitoring in Real-Time Molecular Neuroscience

This book is the third in a series entitled, Compendium of In-Vivo Monitoring in Real-time Molecular Neuroscience. Its purpose is to provide a cross-section of research addressing monitoring in the rodent, and in some cases, the human brain.

Detailed understanding of the neurobiology of the brain is demanding and involves increasingly wider scope of talent ranging from physicists, neurobiologists, chemists, molecular biologists and bioengineers. Coming from varied backgrounds, they do not necessarily understand how to formulate functional issues in a mutually understandable way. This aim of this book is to provide information which can serve as a starting point for understanding such a complex topic.

The authors provide 'tutorial' writing for specialists, as well as material understandable to a wide audience including neuroscientists, those interested in drug discovery, and those using such measurements for diagnosis purposes.
Contents: Real Time Monitoring of Neuromodulators in Behaving Animals Using Genetically Encoded Indicators (Grace O Mizuno, Elizabeth K Unger and Lin Tian)CNiFERs: Cell-based Biosensors with Nanomolar Sensitivity to In-Vivo Changes in Neuromodulation (Daniel M Kircher, Macit Emre Lacin, David Kleinfeld and Paul A Slesinger)Fluorescent False Neurotransmitters (David Sulzer and Dalibor Sames)Functional Connectome Mapping (Daniel Eskenazi, Nao Chuhma, Susana Mingote, Samira Ztaou and Stephen Rayport)Optogenetics (Erik Naylor, Daniel V Aillon and David A Johnson)Electrochemical Imaging of Exocytotic Fusion Events Using Electrochemical Detector Arrays (Shailendra S Rathore, Meng Huang, Ying Zhao, Qinghua Fang and Manfred Lindau)Micro-Nano-Electrode Array (MNEA) Sensors for Real-time, Parallel Detection of Neurotransmitters and Electrophysiology in the Rat Brain (Yilin Song, Wenjing Wei, Guihua Xiao, Ziyue Li, Mixia Wang, Shengwei Xu and Xinxia Cai)Advances in Tailoring Functional Surfaces for In Vivo Monitoring of Reactive Oxygen Species and Related Molecules Involved in Oxidative Stress in the Brain (Limin Zhang and Yang Tian)Real Time Studies of Acetylcholine Release from Single Synapses and Single Cells with Nanometer Spatial Resolution (Mei Shen and Ran Chen)Longitudinal Recordings of Dopamine Transmission During Behavior with Fast-scan Cyclic Voltammetry (Ryan D Farero and Paul E M Phillips)Regionally Distinct Dopamine Release Dynamics Between Striosome and Matrix Compartments of the Striatum: Role in Basal Ganglia Disorders (Armando G Salinas and Yolanda Mateo)Physiological and Drug-Induced Fluctuation in Brain Oxygen and Glucose Assessed by Substrate-Selective Sensors Coupled with High-Speed Amperometry (Eugene A Kiyatkin)Microdialysis of Catecholamines Reveals Ethanol Actions in the Rodent Brain (Saul Jaime and Rueben A Gonzales)The Corticostriatal Communication Problem in Huntington's Disease: Deficits in Ascorbate Release and Glutamate Uptake (George V Rebec)Neurophysiological Monitoring of Potassium (Michael Thompson)Monitoring Brain Injury with Microelectrode Biosensors (Clélia Allioux, Anne Meiller, Baptiste Balança and Stéphane Marinesco)
Readership: Students and researchers in biochemistry, biological chemistry, neurobiology, neuroanatomy, analytical chemistry, cell and molecular biology and biomedical engineering.Brain Real-Time Chemical Monitoring;Optogenetics;Micro/Nanoelectrodes;Neurological Disease;Neurological Injury0Key Features:Broad range of emerging topicsFocus on molecular detectionProminent authors in the field