In this issue, you’ll hear how researchers can investigate the source of emotions, memory, and consciousness for the first time. You’ll learn how better research tools and new insights into the genetics of brain disorders could revive the moribund effort to improve treatments. You’ll hear how a better understanding of the complex systems the brain uses to relay information could lead to massive breakthroughs in memory and computing. You’ll learn about a remarkable experiment where a paralyzed woman used her mind to control a robotic arm. And you’ll hear how Gabriel Kreiman’s single-neuron measurements of unconscious decision-making could someday point to ways we can learn to control ourselves.