A Pox On You, a mystery involving smallpox germ warfare, is disturbingly possible. In this bio-terroist thriller, a multi-millionaire sets up an institute to produce a vaccine for a smallpox mutant. He enlists the aid of an undercover French organization, the Noir, to detect who else has the mutant or is working on a vaccine. Three of the Noirs agents work feverishly to locate the mutant and vaccine before they fall into the hands of powerful individuals intent on blackmailing the world. Moving against a wealthy, sophisticated background, the Noirs agents become involved in multiple murders and their own shadowy past.