Advances in Comparative Physiology and Biochemistry: Volume 3

There is little doubt that an awareness of the parallel occurrence of biological variation and biochemical diversity existed at the time when Darwin (1859) first produced his "Origin of the Species" (see review by Reichert and Brown, 1909), and, although technical difficulties in the manipulation of biochemicals inevitably produced a time lag between the evolutionary speculations of the classic anatomists and those of the biological chemists, there was no shortage of ideas (Krukenberg, 1877-1878; Reichert and Brown, 1909; Kutscher and Ackermann, 1926, Needham et al., 1932).