ELECTROMAGNET QUANTA, ELECTRON FLOW ELECTROPHYSIO LIVING .‪.‬

Electrons are involved in all electrical phenomena, and living cells cannot be an exception. This book takes on a decidedly different approach to existing texts on electrophysiology, by considering electrical physiological processes from the viewpoint of electron flow, rather than the conventional notion of ion movement. It concisely describes the theoretical background of electron density and cellular voltage, before exploring thought-provoking questions such as the relationship between electrolyte distribution and transmembrane potential, and the source of electricity generation in living cells. A new electromagnetic theory of muscular function is presented, and all topics of relevance — including the electrophysiology of invertebrates, plants, fungi and bacteria — are comprehensively covered. Using plain language and more than 40 original illustrations, the author has designed each chapter to provide a succinct overview of an individual topic in a format that appeals to both the expert and the uninitiated. Electromagnetism, Quanta, and Electron Flow in the Electrophysiology of Living Cells proffers a refreshingly new way to understand a fascinatingly old subject. Contents: Acknowledgements About the Author Preface Abbreviations Introduction: Facts and Definitions What about Volts? What is the Current Idea about Cellular Voltage? The Concept of Electron Density Does the Electrolyte Distribution Actually Determine the Trans-Membrane Potential? Where, in Living Cells, is Electricity Generated? Depolarisation (Loss of Cytoplasmic Electron Density) Activation A Test of the Impedance Hypothesis Fast Depolarisation in Conducting Tissue Repolarisation The Calcium, Sodium and Potassium Problems Excitation-Contraction Coupling in Muscles The Effect of the Ca2+ Problem on Cardiac Muscle Electrophysiology Mechanical Restitution and the Optimal Contractile Response Internal Calcium Ion Release and Recirculation Non-Electromagnetic Theory versus Electromagnetic Theory of Muscular Function: Objections to the Non-Electromagnetic Theory of Striated Muscle Different Theories Electromagnetic Theory of Muscle Contraction Electrophysiology of Smooth Muscle Flow-Mediated Dilatation Pulmonary Vessels Non-Vascular Smooth Muscle Hierarchy of Vertebrate Muscle Other Organs: Electrophysiology of Endocrine Glands Electrophysiology of Exocrine Glands Exceptions to Any General Model Central and Autonomic Nervous Systems Receptors Affecting Perception Receptors Initiating Feedback Control Reflexes Summary and General Comments on Vertebrate Animals Invertebrates: The Electrophysiology of Invertebrates Interlude: Electricity Passing Through Flesh Other Organisms: Plants Fungi 'Primitive' Organisms Bacteria Epilogue References Index Readership: Electrophysiologists, clinicians, and students of Biophysics, Physiology, Biochemistry, Biology, Medicine and related courses. 'It is remarkable that any electron flow through the cellular gels is largely ignored in classical texts on cell physiology, which also incorrectly treat the intracellular milieu as a fluid. Dr Noble offers a novelty and tantalizing challenge to the aspiring physiologist by suggesting the incorporation of electron distribution on the cellular gel proteins in the physiology of electrical and contractile properties. The book, by doing so, brings cell physiology indeed closer to the realm of modern physics.' - Henk E D J ter KeursProfessor Emeritus, University of Calgary, Canada 'Mark Noble has had a long and distinguished career in academic and cardiac medicine ... much of which has focussed on electrophysiological mechanisms controlling rate, rhythm and contractile behaviour in the heart. This book, which draws on reflections in his retirement, is a fascinating and iconoclastic survey of electrophysiological processes in both cardiac and many other excitable tissues in the animal kingdom which will interest and alter the understanding of both clinicians and basic scientists in many...