One year after the Michaluk Virus decimated the southeast, Ethan Bennett and his six companions have become as close as family while facing the trials of living in a drastically changed world. Then a mysterious woman arrives at their safe house in Alabama, pleading for assistance in Atlanta. Despite their suspicions that the woman is hiding important information, Ethan and his friends agree to help. But when they're suddenly forced to flee from the infected, the cohesion the group had cultivated is shattered.
As members of the group succumb to the escalating dangers in their path, new alliances form, new loves develop, and old friendships crumble. In the face of unending horror, one man is forced to make the ultimate sacrifice to save his friends, while another reveals secrets that could hold the key to humanity's survival.