Responding to Mayer’s (2015) call for a research-based understanding of how to design multimedia instruction, a team of graduate scholars from Simon Fraser University (Canada) created this interactive, multi-touch eBook. The authors contribute fresh perspectives, critical viewpoints, and original media productions based on theories and research about human learning, framing both the knowns and the unknowns. The primary interest is to better understand the design principles and instructional strategies for multimedia learning across diverse educational contexts in our classrooms, communities, workplaces, and worlds. What distinguishes this research is the thought-provoking integration of cognitive tools and compelling media-rich content designed by the authors, including 360° panoramic images, infographics, interactive data visualizations, photo galleries, popover widgets, scrolling sidebars, quizzes, timelines, tutorials, videos, and more. Readers are invited to think, listen, feel, touch, tap, swipe, pinch, zoom, and explore the 13 leading-edge chapters.