1847. Assuming the identity of a dead Jesuit priest, a survivor of the famine in Ireland travels to South America, where he is tasked with rebuilding the missions among the natives. Inducted into the ways of the Guarani, Father James Carmichael becomes acquainted with ayahuasca and the ways of ritual cannibalism. In a battle with his own gods and demons, the priest fights for the life he has built, his own self the ultimate stake of the struggle. Worlds are shattered, realities crumbled, lives destroyed. His soul victim to the crucible of the New World, what is tempered in the chaos will be outside his control.