Jacob's Ladder: The History of the Human Genome
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- $17.99
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- $17.99
Publisher Description
What makes us as humans all alike and yet as individuals so different?
Jacob's Ladder delivers a remarkably lucid explanation of what the sequencing of the human genome really tells us. Decoding the sequence, evolutionary biologist Henry Gee shows, is just the beginning: seeing the letters and words. The next frontier is in understanding snatches of conversation between genes—how they interact to direct the growth of an organism. Gee takes us into the heart of that conversation, illuminating how genes govern a single egg cell's miraculous transformation into a human being, and how they continue to direct that person's day-by-day development throughout a lifetime.
Gee tells the story of what we know about the genome today and what we are likely to discover tomorrow. As our knowledge advances, we will be able to direct with increasing authority the conversations between genes: not only performing medical interventions but also creating whole scripts directing birth, ancestry, and diversity in a brave new world.
PUBLISHERS WEEKLY
So we've sequenced the human genome. Now what? Gee, a writer for Nature and former professor at UCLA, tackles this question in his examination of how nature generates "form from the formless." Gee takes his title seriously, describing not only the history of human understanding of biology, but also the history of the evolution of the genome itself. Stories of homunculi and Darwin's legendary journey to the Gal pagos lead seamlessly into discussions of the first life to appear on earth. Gee uses comparative genomics to draw a vivid history of the evolution of life, tying together the usually distinct fields of embryology, genetics and evolution. The crowning gem of this work is the last section on the new network theory of genomics. Gee draws the reader into the new field of computational biology and shows that having the sequence of the human genome is just the beginning. By modeling how the thousands of genes act on and with each other, we can finally begin to answer questions like, where do new species come from? How does a single egg turn into a human baby? How does natural selection affect the genome? Why is there any variation at all? The author knows the details of molecular biology, and he's not afraid to use them. The text is littered with terms like "blastocyst," "T4 bacteriophage" and "Hox genes," though all are carefully defined. Because of this level of sophistication, this fine book is difficult enough to be more suitable for the amateur scientist than for the dabbler. 25 illus. not seen by PW.
