The Relationship Between Gamma-Glutamyl Transferase Levels and Chronic Kidney Disease Among Appalachian Adults (Scientific Article) (Report‪)‬

Introduction Serum gamma-glutamyl transferase (GGT), an enzyme responsible for extracellular catabolism of glutathione and a marker of oxidative stress (1) has been shown to be associated with diabetes mellitus (2) and hypertension, (3) which are considered to be independent risk factors for chronic kidney disease (CKD). However, few epidemiological studies have explored the independent relationship between CKD and GGT. (4,5) In this context, we examined the association between gamma-glutamyl transferase and chronic kidney disease in a population-based study of Appalachian adults after controlling for the effect of major confounding factors such as body mass index (BMI), diabetes mellitus, and hypertension.