Lazarus, risen from the dead, faces the dilemma of finding purpose in life until Christ returns. In his quest for peace and solace from the loss of loved ones along the way, he finds little satisfaction in shipbuilding, vineyards, and other enterprises in Cyprus, France, Spain, the New World, New Orleans, Boston, and England.
Over his long life, Lazarus marries, has children, watches them grow to adulthood and give him his first grandchildren. They age and die, leaving Lazarus alone, traveling and plying his trades, until he marries again and the story repeats—children, grandchildren, and the deaths of more loved ones.
He travels with Cortez, fights in the conquest of the Aztecs, and struggles to protect native peoples against the Spaniards in California and New Mexico. He journeys east to New Orleans where he works to establish the first healthcare system. In the midst of the Battle of New Orleans, he tends to the wounded. He moves to New England and participates in building the hospital system in Boston.
Compounded with personal tragedies, Lazarus faces another dilemma because he does not age. He is forced to devise disguises to protect his ageless state or leave and start life anew where no one knows him.
Between the lines, Lazarus never loses his true mission, spreading the good word about Jesus and His life as Lazarus knew him in childhood.