A grave is discovered at a construction site in Neah Bay, Washington. Is it a Native American burial, as some Makah Tribe members claim— or are these the remains of a Spanish colonist of the 1700s, a man accused of romantic involvement with a young Makah woman? And how did the man die? Before these questions can be answered, a deadly new disease strikes. Raving mania and a lethal fever begin to spread among non-Makahs but inexplicably, Makahs are spared. The virus threatens to cause a worldwide epidemic of madness and death.
Dr. Peyton McKean is called in to identify the organism and find a cure. He confronts an old Makah shaman who seems to know more than he is saying about the origins of the virus. Steeped in native lore, Gordon Steel claims this is the legendary Lost Souls Disease, created by Raven to punish the Spaniards, now unleashed on the modern world to plague those who deny the tribe’s treaty-based right to hunt and fish in their traditional ways. As the death toll mounts, Peyton McKean races against time to save humanity—and himself!