Disposition Kinetics of Ciprofloxacin in Normal Rabbits and Changes Observed in Induced Diabetic Condition (Report‪)‬

Byline: S. Bashir, Alamgeer, M. Akram, M. N. Qaisar and H. M. Irfan ABSTRACT: The pharmacokinetic parameters of ciprofloxacin were determined following oral administration of a single dose of 20mg/kg body weight in normal rabbits and these changes were observed in experimentally induced diabetic rabbits. High performance liquid chromatographic method was employed for the estimation of ciprofloxacin in plasma samples. A significant (Pless than0.05) decrease in drug plasma concentration was recorded at 0.17, 0.33,1.0, and 8.0 hrs sampling times, and highly significant (Pless than0.01) decrease of drug concentrations was observed at 0.67 and 12.0 hr in diabetic rabbits, except sampling at 1.50, 2.00, and 4.0 hrs which did not reveal any difference of plasma levels between normal and diabetic rabbits. A highly significant (Pless than0.01) increase in elimination rate constant (83%), and significant (Pless than0.05) increase in absorption rate constant (16.98%), Cmax (calc) (45.83%), and Clearance (15.21%) in diabetic rabbits as compared to the normal animals were observed.