In a world of technological progress, females are the only ones who can pilot the most advanced military unit in history—the Infinite Stratos (IS). With this power, women have seized complete control of all political, social, and economic ventures; leaving men to the fringes of society, made to tend to the whims of their now, female overlords. That is until Orimura Ichika, the sole male found to have IS piloting ability, is thrust into the spotlight, and enrolled at the prestigious IS Academy. Stuck in the middle of a female-dominated population, Ichika sets out to prove men still have a place in this world. Little did he know, he is just the thing these women have been looking for.